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Managing these modifiable risk factors of CKD (Table 1) can help to minimize GFR loss, CVD and secondary immunosuppression in patients with lupus nephritis

Figure 3 Moreover, increased systematic translocation of intestinal metabolites, bacterial particulates, or even microbiota through the damaged intestinal tract (the leaky gut) heightens systemic inflammatory reactions such as Th17/Treg disorder, interleukin-6, IL-1, and tumor necrosis factors alpha that are being implicated in the etiology of depression

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