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Final Thoughts When working with research materials, consistency and proper handling practices are often important considerations
Based on existing evidence, it is anticipated that participants undergoing immediate treatment cessation will experience significant weight regain, consistent with previous trials demonstrating that a substantial proportion of lost weight is regained following withdrawal of pharmacological therapy [11,12]
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A 2025 JAMA Psychiatry trial (Hendershot et al.) tested lower-dose semaglutide over nine weeks and found reductions in some laboratory measures with smaller real-world effects, suggesting the higher 2.4 mg dose may matter
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