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It was not until 2011 that manufacturers were asked to limit the strength of each capsule to 325 milligrams and to add mandated warning labels

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Zhang Y, Ogbu D, Garrett S, Xia Y, Sun J

Notably, disease-induced pathophysiological alterationssuch as gastrointestinal dysmotility and BBB compromise in cerebral ischemia (Wang et al., 2024) - may substantially modify drug disposition parameters (Wang et al., 2022)

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