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The FDA requires therapies to demonstrate clinically meaningful weight reduction (typically 5% body weight sustained over time)

A 2mg injection delivers far more systemic peptide than 2mg in a topical

Early trial data has shown some of the largest reported weight-loss effects in this drug class

The diversity and severity of neurological symptoms related to B12 deficiency can vary, affecting both the central and peripheral nervous systems

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Pain Animal studies have shown beneficial effects of B12 on the regeneration of nerves and the inhibition of pain-signalling pathways, including cyclooxygenase enzymes