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Despite occupying a different location in static structures, Glu1 of exendin-P5 interacts with multiple residues that interact with His1 of the other peptides, including E364 6 .52 , E387 7 .42 , R310 5 .40 and W306 5 .36

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Exceptionally, Tnf and Foxp3 markers were found slightly augmented, and Cd4 and Cd8a strongly reduced in Igf1r fl/fl mice upon LLC challenge