Common Side Effects Dry persistent cough Hypotension Dizziness Hyperkalemia Taste disturbance (metallic taste) Serious Adverse Effects Angioedema (life-threatening) Severe hyperkalemia Acute kidney injury Neutropenia (rare) Contraindications Pregnancy (teratogenic) Bilateral renal artery stenosis History of ACE inhibitor-induced angioedema Drug Interactions Avoid combination with: Potassium supplements Potassium-sparing diuretics (spironolactone) NSAIDs (reduce effect + kidney risk) Other antihypertensives (risk of hypotension) Monitoring Parameters Blood pressure Serum potassium Serum creatinine Renal function Counseling Points Take 1 hour before meals (better absorption) Do not stop suddenly Report swelling of face/lips immediately Avoid potassium-rich salt substitutes Dry cough is common Clinical Pearls First ACE inhibitor developed Short-acting requires multiple daily dosing If patient develops cough switch to ARB (like Losartan) Useful in diabetic patients for kidney protection Summary Captopril is a short-acting ACE inhibitor effective for hypertension and heart failure but requires careful monitoring due to risks of cough, hyperkalemia, and angioedema
Its also sometimes used to check for malnutrition associated with certain health conditions, particularly in children and older adults (5)
The At-Home limit: Many providers recommend using a vial within 28 to 30 days once it has been punctured for the first time, regardless of the BUD on the label
Elevating the Head of the Bed: For nocturnal reflux symptoms, elevating the head of the bed can help prevent acid from flowing back into the esophagus during sleep
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Lipotropics are fat burning amino acids, substances that are naturally produced by the body
