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These findings suggest that titrating the dose can improve the drugs tolerability and support better adherence to the treatment regimen

(2020) 6:e000928

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A large proportion of participants exhibited hormonal imbalances, with one-fourth of participants having elevated FSH, one-third elevated LH, and 74.9% increased estradiol

Clinically observed reductions in lean mass during medically induced weight loss [40] are therefore consistent with a substrate-sensitive vulnerability affecting skeletal muscle maintenance