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No clinical trial has tested this specific question

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Relevant sources include Novo Nordisk and Eli Lilly announcements ( [5] ) ( [23] ), reputable news reports ( [8] ) ( [9] ), and market/technical studies ( [14] ) ( [22] ), as cited throughout

That changed in 2025 with the publication of SURMOUNT-5, the first randomized head-to-head trial, published in the New England Journal of Medicine

It is a natural occurring enzyme in every cell throughout the body that has a pivotal function in energy metabolism (storing and transfer)

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