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Smarter techniques now target distal renal segments & accessory arteries BP reductions of ~10 mm Hg at 6 months, up to 20 mm Hg at 2 years Very low complication rates across thousands of patients Not a replacement for medsbut a pill-sparing adjunct, especially for sympathetic overactivity With U.S

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Investigations on fixed-dose combinations (FDCs) containing DPP-4 inhibitors as monotherapy are also underway to improve treatment simplification and medication adherence

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