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For statistical comparisons, two-tailed Students t-tests were employed for two-group comparisons, while one-way or two-way ANOVA with Bonferroni correction was used for comparisons involving three or more groups

Patient education should emphasize the limited evidence base, experimental nature of treatment, and importance of ongoing monitoring

Water-subtracted spectra were modeled using the fitMAN, a-prior-knowledge based minimization algorithm, and a quantification template including 17 metabolite spectral signatures derived from simulation [52]

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