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112,205,206 Interestingly, chronic liraglutide administration to diabetic mice that had been injected with alloxan prevented the loss of beta-cell mass, which was shown to be due to both an increase in beta-cell proliferation and a decrease in apoptosis

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Apoptosis is the most studied form, involving a series of well-regulated molecular events that lead to the orderly dismantling of the cell, cleared by phagocytes without causing inflammation [243]

4 Mn metabolism in the brain 4.1 Role of Mn in the brain Under normal physiological conditions, Mn serves as a vital cofactor for Mn-dependent enzymes in the brain

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