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However, this technology still faces a series of challenges

The pudendal nerve follows a tortuous path through the pelvic floor and girdle, leaving it vulnerable to compression and tension injuries at various points along its path

inhibit the activity of cyclooxygenase-2 enzyme, reducing the production of pro-inflammatory and pro-oxidant prostaglandins along with lipid peroxidation

Notably, HIF-2, another key HIF family member also regulated by hypoxia and sharing some target genes, may exhibit distinct roles from HIF-1 in ROS regulation, sometimes even promoting ROS generation under specific conditions, highlighting the nuanced complexity of this family in ROS homeostasis [136]