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No Western regulatory-standard trials, and no FDA approval

If you want that story in detail, our guide to what compounded tirzepatide is, how the FDA shortage change affects availability, and who qualifies explains the compounding rules that now apply to this whole class

NICE guidance recommends regular review of patients taking GLP-1 agonists, typically every 3-6 months, to assess treatment response, side effects, and ongoing appropriateness of therapy

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The short-term follow-up period also restricts the understanding of long-term efficacy and potential side effects