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Mice with reduced adipose NNMT, when fed high-fat diets, gained less weight than control mice a striking adipose-specific effect

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doi: 10.1016/j.bbamcr.2016.01.023 47 CalvaniMRedaEArrigoni-MartelliE

Particularly, it was recently demonstrated in a large multiethnic study that the GPx3 loci was strongly associated with a similar motor neuron disease, ALS, perhaps identifying a risk locus for neuronal disease susceptibility 20,38

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Whether this hypothesis is correct or whether accessible disulfides (e.g., within an extended loop or a flexible N- or C-terminus) circumvent such steric limitations remains to be analyzed