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Abbreviations PCOS: Polycystic ovary syndrome MET: Metformin COM: Metformin combined with semaglutide therapy CRP: C-reactive protein WHR: Waist-to-hip ratio UA: Uric acid ALT: Alanine aminotransferase AST: Aspartate aminotransferase TG: Triglycerides TC: Total cholesterol HDL-C: High-density lipoprotein cholesterol LDL-C: Low-density lipoprotein cholesterol WBCs: White blood cells CRP: C reactive protein HbA1c: Glycosylated hemoglobin FBG: Fasting blood glucose FINS: Fasting insulin HOMA-IR: Homeostasis model assessment of insulin resistance SHBG: Sex hormone binding globulin DHEA-S: Dehydroepiandrosterone sulfate E2: Estradiol TEST: Testosterone PRL: Prolactin FAI: Free androgen index LH: Luteinizing hormone FSH: Follicle stimulating hormone AMH: Anti-Mllerian hormone CVAI: Chinese visceral adiposity index hCG: Human chorionic gonadotrophin CV: Coefficients of variation ELISA: Enzyme-linked immunosorbent assay GLP-1 RAs: Glucagon-like peptide-1 receptor agonists WC: Waist circumference HC: Hip circumference HPO: Hypothalamicpituitaryovarian SD: standard deviation References Stener-Victorin E, Teede H, Norman RJ, Legro R, Goodarzi MO, Dokras A, Laven J, Hoeger K, Piltonen TT

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