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The above process creates a self-perpetuating inflammatory loop and sustains tumorigenesis

Changes in the cellular redox state can alter the oxidation state of metabolic enzymes, resulting in changes in their activity and altered flux through upstream and downstream pathways

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Cells were lysed, RNA was extracted and the RNA was submitted to UW-Madison Gene Expression Center for RNAseq

The large-scale observational studies have been particularly impactful