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Typically, low NO concentrations activate cGMP signalling, whereas high levels induce S-nitrosylation-driven feedback loops that reshape Ca 2+ dynamics (Denninger and Marletta 1999)

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Further, BPA antagonizing ER (observed in our genomic data) is associated with increased apoptosis 78 , which is correlated with the observed increase in p-JNK levels and suggests persistent, overlapping genomic and nongenomic effects of low BPA in zebrafish retina

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