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Key takeaway from the 2026 Frontiers in Allergy review: declining and fluctuating estrogen and progesterone modulate mast-cell activity, type 2 inflammation, and vascular permeability, contributing to distinct phenotypes in asthma, allergic rhinitis, chronic cough, skin allergies, drug hypersensitivity, anaphylaxis, and angioedema

JAMA: the journal of the American Medical Association 302, 412 (2009)

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