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Introduction Reactive oxygen species (ROS

doi: 10.1177/03915603241257362 134 CantoPGranadosJBFeria-BernalGCoral-VzquezRMGarca-GarcaETejedaMEet al

Upon stress, corticotropin-releasing factor is released from the hypothalamus, which leads to adrenocorticotropic hormone release from the pituitary which stimulates the production of glucocorticoids (cortisol in human and corticosterone in rodents) in the adrenal gland

In a case report, one patient with similar clinical phenotype, muscle biopsy showed lipid storage and mitochondrial changes on electron microscopy [15]

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