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The rise of mitochondria in medicine

Kandalla PK, Goldspink G, Butler-Browne G, Mouly V (2011) Mechano Growth Factor E peptide (MGF-E), derived from an isoform of IGF-1, activates human muscle progenitor cells and induces an increase in their fusion potential at different ages

Bock T, Pakkenberg B, Buschard K (2005) Genetic background determines the size and structure of the endocrine pancreas

For example, cell-free mtDNA is sensed by TLR9 in endosomes (recognizing CpG DNA) and by Cyclic GMP-AMP synthase (cGAS) in the cytosol (recognizing DNA in general), leading to production of inflammatory cytokines and interferons (1114)

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Compared with healthy volunteers, CSF TMAO levels in AD patients were also significantly increased