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TRIUMPH-4 (December 2025): Topline results from the Phase 3 TRIUMPH-4 investigational trial evaluating the triple hormone receptor agonist in adults with obesity or overweight and knee osteoarthritis, without diabetes, met all primary and key secondary endpoints, with substantial reductions in body weight and improvements in knee pain and physical function also observed

Patients with severe kidney disease (eGFR below 15 mL/min/1.73m) require special monitoring, though mild-to-moderate kidney impairment is not a contraindication to GLP-1 use