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However, oxidative stress or GSH depletion causes TXNIP to dissociate from TXN and instead bind to NLRP3, inducing conformational activation and promoting inflammasome assembly 53,54

Au HCT, Zheng YJ, Le GH, Wong S, Teopiz KM, Kwan ATH, Gill H, Badulescu S, Valentino K, Rosenblat JD, Mansur RB, McIntyre RS (2025) Association of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and neurogenesis: a systematic review

This inflammation not only damages tissues but also contributes to many common hashimotos symptoms , such as fatigue, joint pain, and brain fog