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attend A&E or call 999 Jaundice (yellowing of the skin or eyes), dark urine, or right upper quadrant pain these may indicate gallbladder or liver disease

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Elevated secretion of the cytokines TNF-, IL-6, and IL-1 is associated with elevated neuronal inflammation, which is accompanied by decreased expression of anti-inflammatory mediators including IL-10 (9)

Furthermore, as a member of the TMPRSS family of serine proteases, hepsin plays crucial roles in various biological processes, including maintaining liver architecture, regulating cell growth, and influencing other serine proteases and lipid metabolism (Hsu et al

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Reference Links Gwyer, D., Wragg, N