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Evidently, a low estradiol level may be insufficient to trigger the usual anorectic effects

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Alongside this, they reduce glucagon output from alpha cells, which limits unnecessary glucose release from the liver and helps maintain steadier fasting and post-meal blood sugar levels throughout the day

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Because 5-HT is a precursor for melatonin, sustained IDO and TDO activation in MDD may reduce melatonin synthesis, thereby compromising its mitochondrial regulatory and antioxidant functions [167]