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Indeed, in pre-clinical models, retatrutide, a triple agonist (GLP-1/GIP/glucagon), resulted in greater WL and improved glucose profile compared to tirzepatide through increased energy expenditure and reduced calorie intake [80, 81]

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Wild-type mice were fed with normal diet, while ApoE / mice were fed with HFD containing 0.15% cholesterol and 41% fat (MD12015, Medicine Ltd, Yangzhou, Jiangsu, China) for eight weeks