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The trials target distinct populations: obesity or overweight without type 2 diabetes (TRIUMPH-1), with type 2 diabetes (TRIUMPH-2), severe obesity with established cardiovascular disease (TRIUMPH-3), and obesity with knee osteoarthritis (TRIUMPH-4)
It explains both its ~14.9% peak weight loss in STEP 1 and its dose-limiting nausea profile, gastric-emptying delay is the same pathway that drives upper-GI side effects
The universality of reported effects across these diverse contexts suggests the mechanism operates independently of cultural factors
This isnt uncommon in this space, but I would prefer to feel at least a little more connected to the brand
Kaufman worried that so many patients will drop out that the drug will be considered a failure
Long-term cardiovascular unknowns: Does retatrutide reduce cardiovascular events like semaglutide does, or is the benefit purely from weight loss
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