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Furthermore, the combination of the short-acting formulation exenatide and the long-acting formulation lilaplutide can significantly increase the number of natural pregnancies in PCOS patients (63), the frequency of menstruation, the regularity of the menstrual cycle (64), and the pregnancy rate associated with in vitro fertilization (IVF) (65)

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A qualified healthcare provider must assess individual medical history, baseline labs, and medication interactions before GLP-1 initiation, regardless of side effect profile comparisons