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It has also not undergone any trials to test its long-term safety

Many patients begin seeing results within weeks, with continued weight loss over several months

In addition, rats overexpressing GLP-1R showed improved learning and memory [77], whereas GLP-1 deficiency due to REM sleep deprivation can negatively impact anxiety and depression behaviors [78]

In the phase 2 diabetes trial, hepatic fat fraction measured by MRI-PDFF decreased by a mean of 73% from baseline in the 12 mg group compared with 14% in the placebo group [8]

[DOI] [PubMed] [Google Scholar] 103.Lai Y.C., Liu Y., Jacobs R., Rider M.H