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For instance, in a randomised, placebo-controlled, double-blind Phase I study of ascending single doses of cotadutide in healthy individuals with overweight, there were dose-dependent improvements in glucose excursions post meal within 24 h and food intake reduction after a single dose of 100 g [82]

2.1 Telomere shortening: at the nexus of cellular aging In 2013, telomere attrition was described as a primary hallmark of aging (Lpez-Otn et al., 2013), and its research has increasingly garnered attention in recent years

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STK11/LKB1 mutations affect the phosphorylation of -catenin and regulation of WNT signaling [54]

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