Badenhorst, T., Svirskis, D., Merrilees, M., Bolke, L., & Wu, Z
[8] A safe alternative to the use of drugs carrying important side effects has been the use of peptide-based tolerogenic therapeutics for the induction of immune tolerance to self-antigens though the inhibition of autoreactive T, B, and dendritic cells together with the promotion of the activity of immunoregulatory cell populations
After LPL hydrolyzes TRLs, sortilin, a member of the vacuolar protein sorting 10 (or VPS10) family, facilitates the uptake of secreted LPL and transfers it to endosomes in parenchymal cells, and LPL ends up in lysosomes for degradation [50,84]
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PMID 24665419
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