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Potential Side Effects and Management Like all medications, semaglutide can cause side effects

Endocrinology 146 , 51205127 (2005)

It was included as a tertiary agent in the 2017 edition of the multi-agency clinical guidelines for the treatment of hypertension (Whelton et al, 2018), but was no longer mentioned in the 2025 AHA/ACC multisociety hypertension guidelines (Jones et al, 2025)

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Ozempic is specifically approved for Type 2 diabetes, though weight loss may potentially be a side effect