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[12] Very high cumulative exposure over months may encourage calcium deposition in soft tissues such as the renal parenchyma or coronary arteries, an outcome implicated in observational studies linking supra-physiological 25-hydroxyvitamin D levels with vascular calcification and heightened fracture risk in frail elders

For samples analysed in positive ion mode, mobile phase A comprised of 10 mM ammonium formate with 0.1% formic acid in water and mobile phase B comprised of acetonitrile

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