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Understanding the long-term implications helps set realistic expectations

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Malignant peripheral nerve sheath tumor in the anterior skull base associated with neurofibromatosis type 1

Taken together, these results show that while it is unlikely that direct action in the ARC is the major mechanism for GLP-1RAinduced weight loss, the contributions of genetically distinct subsets of GLP-1Rexpressing neurons in this region have not been fully explored

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Therefore, our conclusions about potential predictive value remain exploratory and hypothesis-generating