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Two separate vials win wherever the ratio has to be varied, wherever an observation needs attributing to one mechanism rather than the pair, or wherever one component is required without the other

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Intrinsic Factor and B12 Absorption: Vitamin B12 is a very large molecule compared to other vitamins and requires an enzyme called intrinsic factor to metabolize effectively

Then there's the impact on blood sugar

This suggests that B12 indeed affects the circadian clock

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