These were measured at baseline and weekly for 10 weeks (on Days 7, 14, 21, 28, 35, 42, 49, 56, 63, and 70)
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According to Mankin et al, the rigorousness of the OA destruction was categorized using the histologic standards (Table 2) based on structural variations (scale range 06), cellular variations (scale range 03), damage of safranin O staining (scale range 04) and tidemark integrity (scale range 01) by 3 independent researchers
To compare hormone treatment and placebo, 120 patients were divided into randomized groups
Inhibitory kinetic studies Inhibitory kinetic studies were performed in the absence and presence of increasing concentrations (0.25, 0.5, 1, and 2 mM) of IAA, IPA, and IBA
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