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These medications can influence digestion and appetite and may contribute to changes in hydration and lean muscle mass during weight loss
Both medications have shown strong results for weight management
Figure 2 To unravel the precise signaling pathway linking metformin to the NR4A nuclear receptor family requires further studies, but it is worthy of note that the orphan receptor, Nur77, regulates LKB1 localization and is also important for the regulation of glucose uptake into C212 mouse muscle cells (184, 185)
