Pharmacologic Inhibition of Glutathione Reductase Reduces Airway Inflammation, Lung Injury, and Cell Death To investigate the role of glutathione reductase in influenza-induced lung injury in vivo , we examined the impact of lomustine, a potent glutathione reductase inhibitor, on mice after influenza infection (Figure 7A)
Numerous conditions can alter the level of GSH synthesis via changes in glutamate-cysteine ligase activity and expression of the GCLC gene such as oxidative stress, antioxidant levels, hormones, cell proliferation, and diabetes mellitus
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In contrast, the in vitro reduction of Escherichia coli RNR or PR was shown to require both active-site cysteinyl residues of glutaredoxin 1 (EcGrx1) 41,57
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