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Discussion Clinical trials have indicated that leptin administration failed as an efficient therapeutical approach to treat obesity 24,25,26 , although it attenuates the neuroendocrine and metabolic changes induced by weight loss 1,2,3,4,5
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Safety and tolerability in the AD population were consistent with the known profile of semaglutide in other indications, with adverse events such as gastrointestinal symptoms and weight loss reflecting its established effects