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Any condition affecting the gastrointestinal tract, such as autoimmune gastritis (which can lead to pernicious anaemia), celiac disease, Crohns disease, or surgical procedures like gastric bypass surgery, gastrectomy or terminal ileal resection, can impair the absorption of B12, and increases the chance of developing vitamin B12 deficiency

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Although clinical trials are limited, the evidence suggests that B12 injections at a dose of at least 500 g three times per week for 2 weeks are effective in relieving chronic low back pain

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248 Theoretical risks include health problems in offspring related to genetic and epigenetic effects of oxidative stress, which may occur as a result of the procedure or may be inherited via the infertile father