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1862, no

For example, many supplements contain caffeine, which acts as a diuretic and eliminates fluid from your body, per the NIH

Administration of oligofructose-enriched inulin (p-inulin) in 15 patients with CKD in a 3-phase pilot trial revealed a marked alteration in the gut microbiota composition with an increase in abundance of Bifidobacterium and Anaerostipes

That matters because over 30 enzyme systems depend on copper collagen cross-linking, free radical cleanup, mitochondrial energy production

The agency's advisory panel voted in support of the restrictions at the time, though several of those advisers and internal staff no longer work for the agency

PMID 8299004