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It is known that SNVs in the ABCB1 gene can directly affect the uptake of VPA by the brain and also the excretion (efflux) of VPA from the brain into the blood

However, these microbehost interactions are likely the tip of the iceberg, as the bacteria in the gut contain numerous genes, likely corresponding to an extensive degree of functionality

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Silva-Gomes, S

10.1089/ars.2006.8.1865

Biochem Biophys Res Commun 482:419425 Wu G, Fang YZ, Yang S, Lupton JR, Turner ND (2004) Glutathione metabolism and its implications for health