Second, it blocks the reuptake process that normally removes neurotransmitters from the synapse
In these trials, the average weight loss for patients on semaglutide (the active component of Wegovy and Ozempic) was 15%-17% after 68 weeks
Cagrilintide (Cagri), a long-acting amylin analogue that targets amylin receptors in the hindbrain, reduces food intake and body weight in mice 21
Important considerations include: GLP-1 agonists are generally well-tolerated in people with hypertension They do not typically cause dangerous drops in blood pressure Dehydration from gastrointestinal side effects (nausea, vomiting, diarrhoea) can occasionally affect blood pressure and kidney function, so maintaining adequate fluid intake is important If you take diuretics (water tablets), ACE inhibitors or ARBs for blood pressure, your doctor may monitor you more closely during the initial weeks of GLP-1 therapy Seek medical advice promptly if you experience persistent gastrointestinal symptoms that prevent adequate fluid intake NICE guidance (NG28) supports the use of GLP-1 agonists in people with type 2 diabetes who meet specific criteria, with preference for agents with proven cardiovascular benefits in those with established cardiovascular disease
Lustig RH: Autonomic dysfunction of the -cell and the pathogenesis of obesity
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