A fully artificial pancreas versus a hybrid artificial pancreas for type 1 diabetes: a single-centre, open-label, randomised controlled, crossover, non-inferiority trial
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doi: 10.1016/j.neuron.2006.09.021
Optimal metabolic function requires both sufficient hormone production and robust receptor-mediated signaling
In addition to being administered as a drug to cause oxidative stress, MTX has also been used to induce cachexia, anorexia, intestinal mucositis and digestive absorption problem in experimental animal models (Reference Boukhettala, Leblond and Claeyssens34Reference Sinno, Coquerel and Boukhettala36)
Higher concentrations are space-efficient and practical at higher doses but demand careful technique for small doses