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On the other hand, MEDI0382 has been more extensively examined in multiple phase 2 RCTs, on diabetic obese patients, exhibiting significant reductions in blood glucose and body weight, 4850 alone or in combination with other antihyperglycemic agents (NCT02548585, NCT03444584, NCT03645421, NCT03244800, NCT03235050, NCT03745937, NCT03596177, NCT04019561)

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Adequate calcium, protein, vitamin D, and weight-bearing exercise are essential

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