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A review published in Regulatory Toxicology and Pharmacology stated that the evidence of safety is strong at intakes up to 2000mg/day l-carnitine equivalents for chronic supplementation. The authors went on to note that taking higher levels had not shown any safety risks

Even in small amounts, licorice can worsen fluid buildup in the body, which is a common problem for those with kidney disease

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Therefore, people with these conditions should use L-carnitine with caution

First, exploring the long-term effects of L-carnitine supplementation on endurance performance would be beneficial, as this study was limited to short-term supplementation

Moreover, metabolic optimization before pregnancy improves maternal and fetal outcomes