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Its about catching up to the science

515 Preliminary data have shown that the pharmacological effects of IGF-1 affect synaptic development primarily by modulating the MAPK and mTOR pathways, as validated in PhelanMcDermid syndrome and Rett syndrome

doi: 10.3109/15563650.2013.844822

547 Metabolic decline of aged astrocytes is also well documented

doi: 10.1002/jmri.27530 24 BlairI