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This suggested either the existence of an alternate receptor for GLP-1 and/or GLP-1(936), or receptor-independent mechanisms of action

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- Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1, NEJM 2022, n=2,539) Wilding JPH et al

More research is needed to determine if the reported improvements in the reproductive parameters are directly related to the GLP1-RA or are due to weight loss, or both

Each column is a titration dose, from the 0.5mg microdose through the 12mg ceiling

The influence of GLP-1 receptor agonists on heart failure with reduced ejection fraction has been investigated so far only by two small clinical trials, the FIGHT and the LIVE trial