The closest published human safety data is for CB4211 , a synthetic MOTS-c analog that completed a Phase 1 trial and was reported as well tolerated
Most patients find that gastrointestinal symptoms diminish over time as the body adjusts to the medication, usually within 48 weeks
Proc Natl Acad Sci USA 2010
This translated to an 8% lower risk for death due to any cause for those treated with GLP-1 medications (HR = 0.92
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