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Measurable structural changes, such as improved skin density and enhanced hair follicle activation, generally become visible within 48 weeks of regular therapy

This may result from excessive copper chelation or disruption of the extracellular matrix

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pubmed.ncbi.nlm.nih.gov/18644225

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Consistent with this, BDNF and p-CREB protein levels in the contralateral hippocampus were significantly increased in the low-intensity exercise group, suggesting that 2 weeks of low-intensity treadmill exercise helped improve cognitive function and increased hippocampal BDNF expression after severe TBI [123]