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2 Ferroptosis in OA: molecular mechanisms and pathological significance 2.1 Ferroptosis in OA pathogenesis: emerging connections Characterized by iron dysregulation and lipid peroxide overload, ferroptosisoriginally triggered by the small molecule erastinwas formally defined in 2012 by Dixons seminal work (Yang J

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3D), characterized by increased proximity to Stranger 1 and reduced non-social exploration

GLP-1 medications strengthen the intestinal barrier and improve gut dysbiosis patterns, reducing bacterial endotoxin translocation

It is also gentle on sensitive skin

Due to muscle edema and decreased myoelectric rhythm, patients with hypothyroidism often have gastric motility disorders, resulting in delayed gastric emptying and gastric acid deficiency